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simeprevir (smv; ns3 inhibitor)  (Acme Bioscience)

 
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    Acme Bioscience simeprevir (smv; ns3 inhibitor)
    Simeprevir (Smv; Ns3 Inhibitor), supplied by Acme Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simeprevir+smv/simeprevir++smv++ns3+inhibitor+/10__1128_slash_jvi__00619___16-50-13-21
    Average 90 stars, based on 1 article reviews
    simeprevir (smv; ns3 inhibitor) - by Bioz Stars, 2026-09
    90/100 stars

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    other:

    Article Title: Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis
    Article Snippet: The direct-acting antivirals (DAAs) daclatasvir (DCV; NS5A inhibitor), sofosbuvir (SOF; NS5B inhibitor), and simeprevir (SMV; NS3/4A inhibitor) were synthesized by Acme Bioscience.



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    Fig. 5. The effect of direct-acting antivirals against ED43-7M mutants and the JFH1 strain. RNA-transfected cells, which were continuously producing HCV particles in the culture medium, were seeded onto poly-L-lysine-coated 96-well plates at 1×104 cells/ well and cultured in the presence of the DAAs (a) <t>simeprevir,</t> (b) ledipasvir or (c) sofosbuvir at indicated concentrations. After 3 days of culture, the HCV core level in the culture medium was measured. The HCV core level of each concentration is shown as a relative value, with the control as 100%. (d) The EC50 was calculated using GraphPad Prism 7.
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    simeprevir (smv; ns3 inhibitor)  (Acme Bioscience)
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    Real-life SVR12 results with different DAA treatment regimens in the Egyptian national program. Note: El Raziky et al and Doss et al. , Abbreviations: SVR, sustained virologic response; DAA, direct-acting antivirals; SOF, sofosbuvir; PEG, pegylated interferon; RBV, ribavirin; <t>SMV,</t> <t>simeprevir;</t> DCV, daclatasvir.
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    Fig. 5. The effect of direct-acting antivirals against ED43-7M mutants and the JFH1 strain. RNA-transfected cells, which were continuously producing HCV particles in the culture medium, were seeded onto poly-L-lysine-coated 96-well plates at 1×104 cells/ well and cultured in the presence of the DAAs (a) simeprevir, (b) ledipasvir or (c) sofosbuvir at indicated concentrations. After 3 days of culture, the HCV core level in the culture medium was measured. The HCV core level of each concentration is shown as a relative value, with the control as 100%. (d) The EC50 was calculated using GraphPad Prism 7.

    Journal: The Journal of general virology

    Article Title: Establishment of infectious genotype 4 cell culture-derived hepatitis C virus.

    doi: 10.1099/jgv.0.001378

    Figure Lengend Snippet: Fig. 5. The effect of direct-acting antivirals against ED43-7M mutants and the JFH1 strain. RNA-transfected cells, which were continuously producing HCV particles in the culture medium, were seeded onto poly-L-lysine-coated 96-well plates at 1×104 cells/ well and cultured in the presence of the DAAs (a) simeprevir, (b) ledipasvir or (c) sofosbuvir at indicated concentrations. After 3 days of culture, the HCV core level in the culture medium was measured. The HCV core level of each concentration is shown as a relative value, with the control as 100%. (d) The EC50 was calculated using GraphPad Prism 7.

    Article Snippet: Simeprevir (SMV) was purchased from MedChemExpress.

    Techniques: Transfection, Cell Culture, Concentration Assay, Control

    Real-life SVR12 results with different DAA treatment regimens in the Egyptian national program. Note: El Raziky et al and Doss et al. , Abbreviations: SVR, sustained virologic response; DAA, direct-acting antivirals; SOF, sofosbuvir; PEG, pegylated interferon; RBV, ribavirin; SMV, simeprevir; DCV, daclatasvir.

    Journal: Hepatic Medicine : Evidence and Research

    Article Title: Hepatitis C infection in Egypt: prevalence, impact and management strategies

    doi: 10.2147/HMER.S113681

    Figure Lengend Snippet: Real-life SVR12 results with different DAA treatment regimens in the Egyptian national program. Note: El Raziky et al and Doss et al. , Abbreviations: SVR, sustained virologic response; DAA, direct-acting antivirals; SOF, sofosbuvir; PEG, pegylated interferon; RBV, ribavirin; SMV, simeprevir; DCV, daclatasvir.

    Article Snippet: Similar negotiations with the other DAA manufacturers led to equivalent reduction of prices: simeprevir (SMV) (Janssen) and daclatasvir (DCV) (Bristol-Meyers-Squibb) at $250, paretaprevir–ombitasvir (AbbVie) and SOF–ledipasvir (Gilead Sciences) for the equivalent of $300.

    Techniques: